Archives of Reading List

Modeling GRN dynamics in hematopoiesis dx.doi.org/10.1016/j.devcel.2016.01.024

By integrating dynamic gene expression data and prediction of cis-regulatory elements by analysis of chromatin marks and transcription factor binding, the authors model gene regulatory network dynamics for six developmental stages from embryonic stem cells to macrophage to identify new regulatory linkages and aid future predictions. And they built a cool, interactive web site! http://www.haemopoiesis.leeds.ac.uk/data_analysis/

Functionally redundant isoforms MEK1 & MEK2

dx.doi.org/10.1126/scisignal.aad5658/ Kinases MEK1 & MEK2 are functionally redundant in mice placenta. Loss of either leads to differential viability of mice embryos. The authors found that, by varying the genomic copy number of these critical enzymes, these isoforms were sufficient to compensate for the loss of the other provided that a threshold amount of either MEK1 or MEK2 […]